The development of low-cost non-precious-metal catalysts for alkaline fuel cells, especially for the hydrogen oxidation reaction (HOR), has faced challenges due to the instability of these materials. To address this issue, a Quantum Well Catalytic Structure (QWCS) has been introduced, where Ni nanoparticles are atomically confined within a heterojunction. This structure, named Ni@C-MoOx, enhances catalytic activity while maintaining stability by preventing Ni oxidation and improving the hydrogen oxidation reaction. The QWCS functions similarly to a quantum well transistor, regulating electron transfer based on the adsorption of reactants and changing the electronic conductivity of the catalyst. Through structural characterization, including X-ray diffraction and spectroscopy analysis, the successful fabrication of the Ni@C-MoOx catalyst was confirmed, showing improved stability and efficiency for alkaline fuel cells. The innovative design of the QWCS offers a promising solution to the stability challenges faced by Ni-based catalysts, crucial for the advancement of fuel cell technology.