The article discusses the potential of CO2 hydrogenation to produce methanol as a means of mitigating greenhouse gas emissions. Traditional methods using metal oxides have limitations due to high temperatures and energy consumption. An alternative approach involving amine-assisted two-step CO2 hydrogenation shows promise at lower temperatures. The article highlights the challenges of homogeneous catalysts and the need for optimization in both N-formylation and amide hydrogenation steps. The study presents the synthesis of Ru-containing heterogeneous catalysts on Al2O3 support, with different Ru species exhibiting varied catalytic activities. Experimental results demonstrate the effectiveness of the Ru-2 catalyst with a dominant distribution of Ru clusters in achieving high selectivity (>95%) and morpholine regeneration (>99%) during methanol production from CO2. DFT analysis confirms the role of metallic and oxidized Ru species in different steps of the reaction. The work emphasizes the importance of active species heterogeneity in enhancing catalytic performance for sequential reactions, offering a novel pathway for CO2 hydrogenation towards methanol with improved efficiency and stability.