The escalating consumption of fossil fuels has prompted a growing interest in renewable and eco-friendly energy sources, with hydrogen emerging as a promising alternative. Electrochemical water electrolysis is a key method for producing green hydrogen but is hindered by the high cost of precious metal-based catalysts. To address this challenge, researchers have turned to high-entropy materials (HEMs) as potential catalysts for water electrolysis. The study, led by researchers from Shanghai University and other institutions, delves into the synthesis, properties, and applications of HEM catalysts. By reviewing the preparation strategies for HEMs and exploring their catalytic mechanisms, the team has highlighted the unique properties of HEMs, such as rich active sites and enhanced entropy stability. Nanoscale HEMs, in particular, exhibit a larger specific surface area and stronger adsorption capacity, making them highly effective for catalytic applications. The research progress presented in the study offers insights into the potential of HEMs to revolutionize catalysis, providing a sustainable and efficient solution for clean energy production. The development of HEM-based catalysts is seen as a significant step towards accelerating the shift towards clean energy and supporting the hydrogen economy.