Nanoscale materials have long been known for their unique properties, with quantum dots and graphene being notable examples. Covalent organic frameworks (COFs) have emerged as promising materials for various applications, including photocatalysis. In a recent study, researchers successfully synthesized two nano-COF colloids, TFP-BpyD and TFP-BD, exhibiting high photocatalytic activity for hydrogen production. These nano-COFs, with distinct morphologies, were prepared in water under ambient conditions using surfactants, allowing for scalable production. Remarkably, the TFP-BpyD nano-COF achieved a hydrogen evolution rate of 392.0 mmol g−1 h−1, showcasing its efficiency. The study also uncovered a reverse concentration-dependent phenomenon affecting hydrogen production, elucidated through photophysical measurements. The bottom-up synthesis approach and improved properties of these nano-COFs offer exciting prospects for advancing photocatalysis and renewable energy research.