A team of researchers from various prestigious institutions visualized the catalytic process of hydrogen conversion by microorganisms using nuclear magnetic resonance spectroscopy. By leveraging parahydrogen-induced polarization (PHIP), they were able to identify and study the intermediates in the catalytic cycle of [Fe]-hydrogenases, a significant advancement in the field. The study revealed how [Fe]-hydrogenases bind hydrogen during catalysis, highlighting the formation of a hydride at the iron center. This innovative approach not only allowed for the observation of previously unknown steps in the conversion process but also facilitated the investigation of binding kinetics. The high sensitivity of PHIP makes it a promising tool for studying hydrogen metabolism in living cells, potentially paving the way for the development of more productive (bio)catalysts for hydrogen conversion. The findings hold promise for a more sustainable energy economy, as hydrogen emerges as a viable alternative to fossil fuels. This research contributes valuable insights into the efficiency and eco-friendliness of hydrogen production processes, with implications for future advancements in the field of energy conversion and catalysis.