The article discusses the challenge of finding noble metal-free catalysts for efficient hydrogen evolution and conversion, highlighting the potential of hydrogenases, natural enzymes, as alternatives. The study delves into [Fe]-hydrogenases' catalytic cycle, previously difficult to characterize. By employing sensitivity-enhanced NMR with parahydrogen, the research team identified enhancement effects on reaction products, revealing transiently bound hydrogen species. The parahydrogen-induced polarization (PHIP) effects facilitated the observation of NMR signals, offering insights into the catalytic mechanism of hydrogenases. The study emphasizes the significance of PHIP in studying metalloenzymes like hydrogenases, showcasing its promise in advancing understanding of energy conversion processes and potentially informing the development of efficient catalysts in the future.