A recent international study has demonstrated the benefits of inhaling hydrogen-rich gas (HRG) before exercise as a strategy to reduce fatigue and enhance performance in athletes and fitness enthusiasts. The research involved a cross-disciplinary team from the U.S. and China, as well as the Hebrew SeniorLife’s Hinda and Arthur Marcus Institute for Aging Research. Participants who inhaled HRG before cycling showed lower perceived fatigue and improved exercise performance compared to those who inhaled a placebo gas. The study highlighted the positive impact of HRG on reducing oxidative stress markers and enhancing functional performance. Key findings of the research included participants reporting lower fatigue levels after inhaling HRG, improved cycling frequency, reduced perceived exertion during exercise, and decreased oxidative stress markers post-exercise. While some parameters like counter-movement jump height were not significantly affected by HRG inhalation, the overall benefits on fatigue and oxidative stress were evident. The study suggests that using HRG inhalation before exercise could be a valuable strategy for athletes and fitness enthusiasts aiming to boost their performance and recovery. By potentially mitigating fatigue and improving markers of oxidative stress, HRG may support more effective training and overall health outcomes. The research opens up new possibilities for utilizing hydrogen-rich gas in sports and exercise science, with the potential for widespread adoption to enhance athletic performance and combat exercise-induced fatigue.