Hydrogen isotopes have garnered significant attention for their potential role in the energy transition. Researchers from Leipzig University and TU Dresden, part of the Hydrogen Isotopes 1,2,3H Research Training Group, have made a breakthrough in efficiently separating hydrogen isotopes. The study, recently published in Chemical Science, focuses on addressing the challenges of providing highly pure isotopes in a cost-effective and energy-efficient manner. By exploring the use of porous metal-organic frameworks, the team aims to enhance isotope separation methods at room temperature, moving away from the current energy-intensive processes used at very low temperatures. The team's research sheds light on the intricate interplay of the framework environment on the binding selectivity of isotopes. Through advanced spectroscopy, quantum chemical calculations, and chemical binding analysis, the researchers have gained insights into optimizing materials for high selectivity at room temperature. This paves the way for the development of more efficient isotope separation methods. Funded by the German Research Foundation, the 1,2,3H Research Training Group is dedicated to training doctoral researchers in the field of hydrogen isotopes. The interdisciplinary collaboration between various institutions aims to advance research in materials, pharmaceuticals, and detection methods related to hydrogen isotopes. The group's efforts signify a significant step towards realizing the potential of hydrogen isotopes in various applications, including sustainable energy sources and pharmaceutical development.