Companies worldwide are increasingly focused on achieving net-zero carbon emissions, emphasizing the importance of decarbonizing transportation fleets, particularly medium- and heavy-duty vehicles. With 1% of vehicles contributing to 20% of emissions, a global effort to transition to emissions-free transportation is underway. This shift necessitates a blend of technologies, including electric, hydrogen fuel cell, and renewable fuels for internal-combustion engines. The sector is in the early stages of manufacturing and operationalizing alternative fuel vehicles, with regulatory frameworks, technological advancements, incentives, and driver acceptance playing key roles in adoption. California's ambitious Advanced Clean Trucks regulation requires a significant portion of vehicles to be zero-emission by 2035, influencing other states and driving market change. Innovators like Tesla, Daimler, Volvo, and Nikola are leading the way with electric and hydrogen fuel cell trucks, supported by federal and state funding for clean energy projects. Companies like Revoy and startups TeraWatt and WattEV are building infrastructure for EV charging and hydrogen refueling to facilitate fleet transition. Understanding the total cost to transport is crucial for fleets considering the shift to electric and autonomous vehicles, with factors like vehicle costs, fuel expenses, and maintenance impacting the decision. Despite market challenges and cost factors, taking steps towards net-zero carbon fleets is essential. To navigate this transition, supply chain executives can engage with manufacturers, evaluate charging infrastructure needs, and explore financial incentives available. By testing low-risk experiments and gaining early expertise, companies can pave the way for a sustainable transportation future.