To achieve its 2050 decarbonization targets, the United States is placing a strong emphasis on tripling its nuclear power capacity by adding over 200 GW through key strategies such as deploying advanced reactors, streamlining regulations, and boosting public-private partnerships. Currently operating 94 nuclear reactors, the U.S. aims to leverage Gen III+ and Generation IV reactors to meet the increased capacity demands. The focus is on making nuclear energy more affordable by selecting and standardizing reactor designs, with an eye on various market needs like large-scale electricity generation and industrial applications of high heat. Additionally, expanding to Small Modular Reactors (SMRs) and microreactors is seen as crucial for cost reduction and wider deployment. Securing reactor orders, timely project delivery, and scaling the industry workforce are highlighted as essential steps for nuclear expansion. The U.S. also faces the challenge of significantly boosting its uranium supply chain capacities across mining, milling, conversion, and enrichment to meet the future demands of nuclear power. By maximizing factory production and reducing on-site construction, the U.S. nuclear industry aims to become more competitive in the clean energy sector.