A team led by Professor Liang Chen at the Ningbo Institute of Materials Technology and Engineering in China has developed a groundbreaking high-entropy electrocatalyst with the ability to efficiently generate hydrogen and valuable glycerol-derived chemicals simultaneously. Published in Nature Nanotechnology, the research addresses the limitations of commercial hydrogen production through water electrolysis, particularly the inefficiencies of the oxygen evolution reaction (OER) at the anode. By creating a high-entropy nanostructured catalyst consisting of platinum, copper, cobalt, nickel, and manganese (PtCuCoNiMn), the team successfully increased the selectivity for glycerate formation, a high-value chemical obtained from glycerol electro-oxidation. The optimized catalyst demonstrated an impressive 75.2% selectivity at a high current density, showcasing its superior performance in electro-oxidation applications. Remarkably, the catalyst exhibited exceptional stability, maintaining high-performance glycerol electro-oxidation reactions for over 210 hours when implemented in an electrolyzer. This innovative approach not only enhances the sustainability and efficiency of hydrogen production but also offers a cost-effective method for synthesizing valuable chemicals. The study represents a significant step towards achieving carbon peaking and neutrality objectives and signifies a noteworthy advancement in electrocatalysis for green energy conversion and storage applications.