Electrocatalytic water splitting is crucial for generating green hydrogen from renewable electricity, with anion exchange membranes water electrolysis (AEMWE) gaining attention in industrial hydrogen production. However, challenges like high cell voltage and sluggish hydrogen evolution reaction (HER) kinetics exist. This article introduces a novel Ru-GaSA/N-C catalyst for AEMWE, where Ga single atoms enhance metal-support interaction with Ru clusters, improving water dissociation. The catalyst exhibits outstanding performance, surpassing Pt-based catalysts. Notably, it operates at low voltage and maintains stability over extended periods. The synthesis process involves encapsulating Ga(acac)3 in ZIF-8, pyrolysis to form Ga single atoms on nitrogen-doped carbon, and anchoring Ru clusters on this support. Structural characterization confirms the successful catalyst formation, highlighting its promising potential for efficient HER in AEMWE.