Hydrogen, a zero-emission energy alternative, can be produced sustainably from renewable sources like wastewater. The article discusses the challenges of using catalysts in wastewater environments and the importance of developing stable catalyst materials. Ruthenium and its compounds show promise in water dissociation but face oxidation limitations. PtRuNi-Ox catalysts, designed with twin boundary distortion structures, demonstrate exceptional catalytic efficiency in hydrogen evolution reactions (HER). These nanocages provide numerous active sites and elevated surface energy, enhancing catalytic reactions. The article details the synthesis and characterization of PtRuNi-Ox catalysts, highlighting their hollow nanocage structure with twin boundaries, which contribute to their stability and efficiency. Results show that PtRuNi-Ox outperforms commercial Pt/C in HER activity and maintains stability after 40,000 cycles. The catalyst also shows potential in alkaline freshwater, chemical wastewater, and seawater electrolytes, indicating promising applications in real wastewater treatment for environmental protection.