A team of chemists from the National University of Singapore has made significant strides in the field of artificial photosynthesis by developing hexavalent photocatalytic covalent organic frameworks (COFs) for the production of hydrogen peroxide (H2O2). Unlike the conventional method which relies on costly catalysts and hazardous solvents, this innovative approach mimics natural photosynthesis using sunlight, water, and air as feedstocks. The COFs address key challenges of charge carrier generation, catalytic site availability, and reactant delivery, leading to enhanced efficiency. Published in Nature Synthesis, the research showcases COFs achieving high production rates, optimal quantum yield, and impressive solar-to-chemical conversion efficiency. These COFs sustainably produce significant amounts of pure H2O2 under ambient conditions, marking a substantial advancement in artificial photosynthesis for industrial chemical production.