MOST-H2 is a groundbreaking project under the European Union's Horizon Europe research program, dedicated to advancing hydrogen storage solutions through innovative Metal-Organic Frameworks (MOFs). The project, led by Dr. Theodore Steriotis of National Centre for Scientific Research, aims to revolutionize hydrogen storage to support the transition to sustainable energy systems in Europe. By combining cutting-edge methods and AI tools, MOST-H2 has made remarkable progress in developing high-performance MOFs optimized for hydrogen bonding, with a focus on environmental sustainability. The project has successfully identified novel MOF compounds with superior hydrogen storage capacities, surpassing industry targets and leading to patent applications. Additionally, MOST-H2 has delved into system modeling, heat, and mass transfer analysis to optimize tank design and charging efficiency for practical and scalable storage solutions. By conducting life cycle assessments and techno-economic evaluations, the project emphasizes both environmental and economic benefits of the proposed storage technology. Case studies in Austria and Italy underscore the project's relevance to sustainable transportation, particularly in hydrogen-powered rail systems. Moving forward, MOST-H2 aims to integrate its advancements into a comprehensive lab-to-tank solution, addressing scalability challenges and exploring commercial applications in hydrogen-powered mobility. With a consortium of 16 partners from various European countries, MOST-H2 exemplifies collaborative research efforts towards achieving EU climate and energy transition goals.