The Council of Scientific and Industrial Research (CSIR) in India has been spearheading industrial innovation by reducing reliance on imports and boosting self-sufficiency. Notable innovations include hydrogen-related technologies like hydrogen cylinder type-IV of paracetamol and hydrogen fuel cells. CSIR's strategic shift towards industry collaboration has resulted in successful commercialization of inventions like hydrazine hydrate production and steel sludge management for road construction. The organization's Guwahati declaration outlines a vision to transform India into a science and technology-driven global manufacturing hub by 2047, emphasizing alignment with global supply chains and expanding the manufacturing landscape.