MOST-H2 is a multidisciplinary research initiative in the EU aimed at revolutionizing hydrogen storage through advanced metal-organic frameworks (MOFs). By leveraging cutting-edge methods and tools, the project has made significant advancements towards providing cost-effective, efficient, and environmentally friendly hydrogen storage solutions essential for achieving the EU's climate and energy transition goals. Through the development of novel MOF compounds exceeding performance targets, the project has secured breakthroughs in cryo-adsorptive hydrogen storage technologies. Additionally, by integrating artificial intelligence (AI) in material design, precise predictions for optimized MOF structures have been achieved. The project has successfully identified high-performing MOF compounds through rigorous experimental research and computational analysis, leading to patent applications for novel compounds. Furthermore, advancements in hydrogen storage system modeling and analysis, alongside detailed heat and mass transfer models, are instrumental in optimizing tank design and charging efficiency. MOST-H2 also focuses on evaluating the environmental and economic benefits of the proposed storage technology through life cycle assessments and techno-economic models. This analysis informs scalability, cost reduction, and potential applications in sustainable transportation, such as hydrogen-powered rail systems. Moving forward, the project aims to integrate these advancements into a complete lab-to-tank solution by addressing scalability challenges, enhancing system design, and exploring commercial applications in hydrogen-powered mobility. By bridging laboratory-scale innovations with industrial-scale applications, MOST-H2 supports the transition to sustainable energy systems across Europe. With a consortium of 16 partners from various countries, MOST-H2 is poised to revolutionize hydrogen storage technologies for a greener future.