Spain is strategically positioned to enhance its production of sustainable fuels to become a significant player in Europe's net-zero transition. With the EU targeting a 55% reduction in GHG emissions by 2030, Spain must shift from fossil fuels to renewable energy sources, including embracing renewable molecules. The transport sector, accounting for 30% of Spain's GHG emissions, requires decarbonization through electrification and sustainable fuel deployment. The use of hydrotreated vegetable oil (HVO) has been pivotal in reducing fossil fuel dependency, but Spain faces feedstock limitations, necessitating the development of alternative technologies. As Europe implements the Renewable Energy Directive III (RED III) by 2030, drop-in fuels like HVO will play a crucial role due to their seamless blending capabilities. However, unlocking Spain's sustainable fuel production potential requires collaboration between stakeholders to address challenges and seize opportunities. Regulatory frameworks like RED III and ReFuel EU Aviation aim to increase renewable energy usage in the transport sector through multipliers and specific mandates. Despite the growth of electric vehicles, internal combustion engine vehicles remain predominant in Spain. The article emphasizes the importance of clarity on sustainable fuel offtake, incentives for local production, and technology mix development to effectively decarbonize the transport sector. Strategies to facilitate Spain's transition to sustainable fuels include understanding the benefits and challenges of the HVO pathway, investing in emerging technologies, and navigating the evolving regulatory landscape.