Rotterdam, Netherlands, is undergoing a significant transformation to become a leading hub for decarbonising heavy industry in Europe. The Port of Rotterdam is at the forefront of this effort, with a focus on carbon capture and storage (CCS), hydrogen networks, residual heat systems, and sustainable fuels. The Porthos project, currently under construction, symbolizes the region's commitment to decarbonisation by establishing a pipeline to transport CO2 from local emitters to depleted gas fields under the North Sea. This initiative, alongside other projects like CO₂next, aims to redefine the industrial system's foundations. The vision extends beyond Rotterdam, with plans to connect with Germany's Ruhr region and industrial areas in Belgium via transnational corridors. Infrastructure development, including CO2 terminals and pipelines, supports early-stage CCS markets and the potential for negative emissions technologies. Coordination between governments, private industry, and infrastructure operators is crucial for success. Despite challenges such as regulatory alignment and financing, Rotterdam's projects are paving the way for a CO2 superhighway across Europe. The ultimate goal is to achieve deep decarbonisation while maintaining industrial competitiveness, emphasizing the importance of getting the infrastructure in place swiftly and efficiently.